Roof Plate Spinal Cord

A role for the roof plate and its resident tgfβ related proteins in neuronal patterning in the dorsal spinal cord.

Roof plate spinal cord.

Abstract commissural spinal axons extend away from the roof plate rp in response to a chemorepellent mediated by the bone morphogenetic proteins bmps. The basal plate forms most of the ventral portion of the nervous system including the motor portion of the spinal cord and brain stem. The caudal part later becomes sensory axon part of the spinal cord. Dorsal patterns the spinal cord the roof plate produces bone morphogenetic proteins.

A role for the roof plate and its resident tgfbeta related proteins in neuronal patterning in the dorsal spinal cord. The spinal cord is a long thin tubular structure made up of nervous tissue which extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column it encloses the central canal of the spinal cord which contains cerebrospinal fluid the brain and spinal cord together make up the central nervous system cns. Cas pubmed google scholar. The inferior olivary nucleus mesencephalic nucleus of v and main sensory nucleus of v are also developed from this plate.

Roof plate thin wall region that underlies the dorsal ectoderm epithelium. The adult horn is divided into 6 laminae i to vi. After closure the neural tube forms a basal or floor plate and a roof or alar plate in response to the combined effects of shh and factors including bmp4 secreted by the roof plate. Cell 91 127 138 1997.

Distinct neuronal cell types are generated at characteristic times and positions in the dorsal horn of the spinal cord. The alar plate specifically later on becomes the dorsal gray of the spinal cord and develops into the sensory nuclei of cranial nerves v vii viii ix and x. Tracts formed by axons surround these horns and project both up and down the spinal cord. The alar plate forms the dorsal portions devoted mostly to sensory processing.

The floor plate is a structure integral to the developing nervous system of vertebrate organisms. Located on the ventral midline of the embryonic neural tube the floor plate is a specialized glial structure that spans the anteroposterior axis from the midbrain to the tail regions it has been shown that the floor plate is conserved among vertebrates such as zebrafish and mice with homologous. In humans the spinal cord begins at the occipital. Also from the rhombic lip of the alar plate develops the cerebellum which is considered to be a big exception since alar plate gives rise to.

The roof plate forms in the dorsal midline of the developing spinal cord shortly after neural tube closure as a result of induction by bmp4 and bmp7 both secreted by the dorsal epidermis.